jMorp: Japanese Multi-Omics Reference Panel update report 2023.

Modern medicine is increasingly focused on personalized medicine, and multi-omics data is crucial in understanding biological phenomena and disease mechanisms. Each ethnic group has its unique genetic background with specific genomic variations influencing disease risk and drug response. Therefore, multi-omics data from specific ethnic populations are essential for the effective implementation of personalized medicine. Various prospective cohort studies, such as the UK Biobank, All of Us and Lifelines, have been conducted worldwide. The Tohoku Medical Megabank project was initiated after the Great East Japan Earthquake in 2011. It collects biological specimens and conducts genome and omics analyses to build a basis for personalized medicine. Summary statistical data from these analyses are available in the jMorp web database (https://jmorp.megabank.tohoku.ac.jp), which provides a multidimensional approach to the diversity of the Japanese population. jMorp was launched in 2015 as a public database for plasma metabolome and proteome analyses and has been continuously updated. The current update will significantly expand the scale of the data (metabolome, genome, transcriptome, and metagenome). In addition, the user interface and backend server implementations were rewritten to improve the connectivity between the items stored in jMorp. This paper provides an overview of the new version of the jMorp.

Religiosidade/espiritualidade entre a população brasileira diante da pandemia Covid-19 e a correlação com a qualidade de vida / Religiosity/spirituality among the brazilian population in the face of the Covid-19 pandemic and the correlation with quality of life / Religiosidad/espiritualidad en la población brasileña frente a la pandemia de Covid-19 y la correlación con la calidad de vida

A pandemia causada pelo SARS-CoV-2 (COVID-19) trouxe inúmeros impactos na vida cotidiana, tanto nos aspectos econômicos, como nos emocionais, psicológicos e sociais. Em situações difíceis, as pessoas, muitas vezes, recorrem à espiritualidade ou à religiosidade. O objetivo deste estudo foi investigar a presença da religiosidade/espiritualidade entre a população brasileira diante da pandemia da COVID- 19, correlacionado com a qualidade de vida. É um estudo quantitativo, descritivo e transversal, realizado nos últimos meses de 2020. Os dados foram coletados por meio de respostas aos instrumentos WHOQOL-Bref e o WHOQOL-SRPB, de forma online, por meio do Google Forms®. Utilizou-se o método de amostragem não probabilístico do tipo snowball sampling, totalizando 948 respostas. Os dados foram tabulados por meio do software Microsoft Excel (2019) e analisados estatisticamente, considerando significativo p<0,05. Os dados apresentados mostram de forma enfática como os participantes que pertencem a alguma religião, apresentaram melhor relação nos domínios saúde psicológica, independência, meio ambiente e espiritualidade/religião/crenças pessoais em comparação àqueles que declaram não pertencer a uma religião. No entanto, não houve diferença estatisticamente significativa para os domínios saúde física e relações sociais. Conclui-se que o pertencimento a uma religião pode contribuir para a melhoria da qualidade de vida e auxiliar o enfrentamento das situações desfavoráveis durante a pandemia COVID-19. Diante disso, destaca-se a importância do desenvolvimento de novos estudos sobre o tema, para compreender com mais veemência e detalhamento, a relação dessas variáveis em contextos de crise que possam alterar a rotina de vida das pessoas.

The pandemic caused by SARS-CoV-2 (COVID-19) has brought numerous impacts on daily life, both in economic, emotional, psychological, and social aspects. In difficult situations, people often turn to spirituality or religiosity. The objective of this study was to investigate the presence of religiosity/spirituality among the Brazilian population facing the pandemic of COVID-19, correlated with quality of life. Quantitative, descriptive, cross-sectional study conducted in the last months of 2020. Data were collected by means of responses to the WHOQOL-Bref and the WHOQOL-SRPB instruments, online, through Google Forms®. The non-probabilistic snowball sampling method was used, totaling 948 answers. Data were tabulated using Microsoft Excel software (2019) and statistically analyzed, considering p<0.05 significant. The data presented emphatically show how the participants, who belong to some religion, presented a better relationship in the domains psychological health, independence, and environment and spirituality/religion/personal beliefs compared to those who do not have a religion. However, there was no statistically significant difference for the physical health and social relationships domains. It is concluded that belonging to a religion can contribute to improved quality of life and assist in coping with unfavorable situations during the COVID-19 pandemic. Therefore, the importance of developing new studies on the subject is highlighted, in order to understand more vehemently the relationship of these variables in crisis contexts that can change the routine of people's lives.

La pandemia causada por el SARS-CoV-2 (COVID-19) ha traído numerosos impactos en la vida cotidiana, tanto en los aspectos económicos, emocionales, psicológicos y sociales. En situaciones difíciles, las personas suelen recurrir a la espiritualidad o la religiosidad. El objetivo de este estudio fue investigar la presencia de religiosidad/espiritualidad en la población brasileña que enfrenta la pandemia de COVID- 19, correlacionada con la calidad de vida. Estudio cuantitativo, descriptivo, transversal, realizado en los últimos meses de 2020. Los datos fueron recolectados por medio de respuestas a los instrumentos WHOQOL-Bref y WHOQOL-SRPB, en línea, a través de Google Forms®. Se utilizó el método de muestreo no probabilístico de bola de nieve, totalizando 948 respuestas. Los datos fueron tabulados utilizando el software Microsoft Excel (2019) y analizados estadísticamente, considerando p<0,05 significativa. Los datos presentados muestran enfáticamente cómo los participantes, que pertenecen a alguna religión, presentaron una mejor relación en los dominios salud psicológica, independencia y entorno y espiritualidad/religión/creencias personales en comparación con aquellos que no tienen religión. Sin embargo, no hubo diferencias estadísticamente significativas para los dominios salud física y relaciones sociales. Se concluye que la pertenencia a una religión puede contribuir a mejorar la calidad de vida y ayudar a afrontar situaciones desfavorables durante la pandemia de COVID-19. Por lo tanto, se destaca la importancia de desarrollar nuevos estudios sobre el tema, para comprender con más vehemencia la relación de estas variables en contextos de crisis que pueden cambiar la rutina de vida de las personas.

The collapse of eastern Bering Sea snow crab.

The snow crab is an iconic species in the Bering Sea that supports an economically important fishery and undergoes extensive monitoring and management. Since 2018, more than 10 billion snow crab have disappeared from the eastern Bering Sea, and the population collapsed to historical lows in 2021. We link this collapse to a marine heatwave in the eastern Bering Sea during 2018 and 2019. Calculated caloric requirements, reduced spatial distribution, and observed body conditions suggest that starvation played a role in the collapse. The mortality event appears to be one of the largest reported losses of motile marine macrofauna to marine heatwaves globally.

High school science fair: School location trends in student participation and experience.

The findings reported in this paper are based on surveys of U.S. high school students who registered and managed their science and engineering fair (SEF) projects through the online Scienteer website over the three years 2019/20, 2020/21, and 2021/22. Almost 2500 students completed surveys after finishing all their SEF competitions. We added a new question in 2019/20 to our on-going surveys asking the students whether their high school location was urban, suburban, or rural. We learned that overall, 74% of students participating in SEFs indicated that they were from suburban schools. Unexpectedly, very few SEF participants, less than 4%, indicated that they were from rural schools, even though national data show that more than 20% of high school students attend rural schools. Consistent with previous findings, Asian and Hispanic students indicated more successful SEF outcomes than Black and White students. However, whereas Asian students had the highest percentage of SEF participants from suburban vs. urban schools- 81% vs. 18%, Hispanic students had the most balanced representation of participants from suburban vs. urban schools- 55% vs. 39%. Differences in students' SEF experiences based on gender and ethnicity showed the same patterns regardless of school location. In the few items where we observed statistically significant (probability < .05) differences based on school location, students from suburban schools were marginally favored by only a few percentage points compared to students from urban schools. In conclusion, based on our surveys results most students participating in SEFs come from suburban schools, but students participating in SEFs and coming from urban schools have equivalent SEF experiences, and very few students participating in SEFs come from rural schools.

Unmanned aerial vehicles (UAVs) with thermal infrared (TIR) sensors are effective for monitoring and counting threatened Vietnamese primates.

Monitoring the population size of threatened primate species with minimal disturbance is becoming an outstanding requirement for conservation and wildlife management. Drones with thermal infrared (TIR) and visible spectrum (RGB) imaging are increasingly used to survey arboreal primates, but ground-truthing is still required to assess the effectiveness of drone-based count estimates. Our pilot study aims to assess the ability of a drone with both TIR and RGB sensors to detect, count, and identify semi-wild population of four endangered species of langurs and gibbon in the Endangered Primate Rescue Center (EPRC) in northern Vietnam. We found that TIR imagery enabled higher detection rates compared to RGB imagery and obtained an accurate count with the TIR only after four drone flights. We could identify langurs species based on thermal signature at a flight height of 50 m from the ground level (max tree height = 15 m), via size and shape of the body. With TIR imagery, we were able to record inconspicuous behaviors such as foraging and play. While some individuals initially showed flight or avoidance behaviors when the drone was sighted, these behaviors decreased or were absent on following drone surveys. Our study suggests that monitoring and precisely counting langur and gibbon species populations could be successful with the use of thermal drones only.

On the genes, genealogies, and geographies of Quebec.

Population genetic models only provide coarse representations of real-world ancestry. We used a pedigree compiled from 4 million parish records and genotype data from 2276 French and 20,451 French Canadian individuals to finely model and trace French Canadian ancestry through space and time. The loss of ancestral French population structure and the appearance of spatial and regional structure highlights a wide range of population expansion models. Geographic features shaped migrations, and we find enrichments for migration, genetic, and genealogical relatedness patterns within river networks across regions of Quebec. Finally, we provide a freely accessible simulated whole-genome sequence dataset with spatiotemporal metadata for 1,426,749 individuals reflecting intricate French Canadian population structure. Such realistic population-scale simulations provide opportunities to investigate population genetics at an unprecedented resolution.

Evaluating the Influences of Health Expenditure, Energy Consumption, and Environmental Pollution on Life Expectancy in Asia.

This study examines the effects of health expenditure, energy consumption, CO2 emissions, population size, and income on health outcomes in 46 Asian nations between 1997 and 2019. Cross-sectional dependence (CSD) and slope heterogeneity (SH) tests are utilized due to the close linkages between Asian nations as a result of commerce, tourism, religion, and international agreements. The research uses unit root and cointegration tests of the second generation after validating CSD and SH issues. Due to the results of the CSD and SH tests, it is clear that conventional methods of estimation are inappropriate, so a new panel method, the inter autoregressive distributive lag (CS-ARDL) model, is used instead. In addition to CS-ARDL, the study's results were checked with a common correlated effects mean group (CCEMG) method and an augmented mean group (AMG) method. According to the CS-ARDL study, higher rates of energy use and healthcare spending lead to better health outcomes for Asian countries over the long run. CO2 emissions are shown to be harmful to human health, according to the study. The influence of a population's size on health outcomes is shown to be negative in the CS-ARDL and CCEMG, but favorable in the AMG. Only the AMG coefficient is significant. In most instances, the results of the AMG and CCEMG corroborate the results of the CS-ARDL. Among all the factors influencing life expectancy in Asian countries, healthcare spending is the most influential. Hence, to improve health outcomes, Asian countries need to take the required actions to boost health spending, energy consumption, and long-term economic growth. To achieve the best possible health outcomes, Asian countries should also reduce their CO2 emissions.

Manual de organización y funciones de la Dirección de Inmunizaciones / Manual of organization and functions of the Directorate of Immunizations

La Dirección de Inmunizaciones, es una dirección especializada del Ministerio de Salud de El Salvador, que tiene asignada la rectoría de todos los aspectos relacionados a la vacunación e inmunización de la población salvadoreña. Esta Dirección es el resultado de una acción conjunta entre los países de la Región de las Américas y de organismos internacionales como la Organización Mundial de la Salud (OMS), su interés es contribuir con acciones tendientes a lograr coberturas universales de vacunación, con el fin de disminuir las tasas de mortalidad y morbilidad causadas por las enfermedades inmunoprevenibles y está sujeta conforme a la Ley de Vacunas. En este sentido y para documentar la organización y funcionamiento de dicha Dirección, se ha elaborado el presente manual como un instrumento técnico normativo de gestión institucional, en el cual se integra la organización y funcionamiento de las diferentes dependencias que lo componen, se describen y establecen los objetivos generales y específicos, las relaciones de autoridad y dependencia de cada ambiente, así como las relaciones de trabajo internas y externas. Tiene el propósito de identificar con claridad las funciones de cada una de las áreas administrativas que la integran, evitar la duplicidad de funciones, conocer las líneas de comunicación y de mando; permitiendo así contar con un instrumento técnico administrativo integrado, que sirva de referencia y consulta a todo el personal laborando en la institución

The Immunization Directorate is a specialized department of the Ministry of Health of El Salvador, who is assigned the rectory of all aspects related to vaccination and immunization of the Salvadoran population. This Address is the result of an action collaboration between the countries of the Region of the Americas and international organizations such as the World Health Organization (WHO), its interest is to contribute with actions aimed at achieving universal vaccination coverage, in order to reduce the rates of mortality and morbidity caused by vaccine preventable diseases and is subject to according to the Vaccination Law. In this sense and to document the organization and operation of said Directorate, has prepared this manual as a regulatory technical management instrument institution, which integrates the organization and operation of the different dependencies that compose it, describe and establish the general objectives and specific, the relationships of authority and dependency of each environment, as well as the internal and external working relationships. Its purpose is to clearly identify the functions of each of the areas that integrate it, avoid duplication of functions, know the lines of communication and command; thus allowing to have a technical administrative instrument integrated, that serves as a reference and consults all the personnel working in the institution

Sobrevida en población pediátrica con leucemia linfoblástica aguda tratada con protocolo ALLIC-BFM de quimioterapia. Revisión sistemática / Survival of pediatric population with acute lymphoblastic leukemia treated with ALLIC-BFM chemotherapy protocol. Systematic review

La leucemia linfoblástica aguda constituye la neoplasia infantil más frecuente. Los tratamientos actuales posibilitan más del 80% de supervivencia libre de enfermedad por cinco años. En el 2000, se probó un protocolo de quimioterapia llamado leucemia linfoblástica intercontinental Berlín-Frankfurt-Münster (ALLIC BFM). El proceso investigativo se realizó mediante la metodología PRISMA, con el propósito de sistematizar la información acerca de la supervivencia de los pacientes pediátricos con leucemia linfoblástica aguda tratados con el uso del protocolo de quimioterapia ALLIC BFM en sus versiones de 2002 o 2009. La supervivencia global en pacientes donde se utilizó el protocolo de 2002 fue del 52% al 91,7% y la libre de enfermedad fue del 45% a 83,3%; mientras que, con el uso del protocolo 2009 se reportó una supervivencia global del 71,1% al 90% y la libre de enfermedad fue del 69,4% al 90,3%. Los principales factores que afectaron la supervivencia fueron las complicaciones relacionadas con el tratamiento, los pacientes de alto riesgo y la medicación insuficiente.

Acute lymphoblastic leukemia is the most common childhood neoplasia. Current treatments allow more than 80% disease-free survival for five years. In 2000, a chemotherapy protocol called Berlin-Frankfurt-Münster intercontinental lymphoblastic leukemia (ALLIC BFM) was tested. The investigative process was carried out using the PRISMA methodology. This study aimed to systematize the information about the survival of pediatric patients with acute lympho-blastic leukemia treated with the ALLIC BFM chemotherapy protocol in its 2002 or 2009 versions. 52% to 91.7% of patients showed an overall survival in patients where the 2002 proto-col was used, and disease-free was from 45% to 83.3%; while, with the use of the 2009 protocol, an overall survival of 71.1% to 90% was reported, and disease-free survival was 69.4% to 90.3%. The main factors affecting survival were treatment-related complications, high-risk patients, and insufficient medication.

Trajetórias socioeconômicas compartilhadas no Brasil: cenários para a dinâmica populacional e os desafios à adaptação e mitigação / Shared socioeconomic pathways in Brazil: Scenarios for population dynamics and the challenges to adaptation and mitigation / Trayectorias socioeconómicas compartidas en Brasil: escenarios de dinámica poblacional y desafíos para la adaptación y mitigación

Resumo Dentre os múltiplos avanços científicos na compreensão das relações entre mudanças climáticas e dinâmica populacional, uma das principais inovações ocorreu na atual geração de modelagem climática, com a inclusão de um conjunto de cenários em que as questões populacionais são centrais. Baseados em narrativas de trajetórias socioeconômicas, estes cenários traçam alternativas para os desenvolvimentos sociais futuros, que, por sua vez, consideram projeções populacionais multidimensionais, construídas a partir das variáveis sexo, idade e escolaridade. Tais projeções incorporam heterogeneidades populacionais relevantes para a adaptação, sendo, potencialmente, mais sensíveis às mudanças na dinâmica demográfica e à compreensão da relação população e ambiente. No Brasil, contudo, tanto os pressupostos como as implicações desta abordagem são quase inexistentes. O presente artigo aborda esta discussão para o país, considerando seus aspectos teóricos e metodológicos. Destacam-se algumas das inferências da abordagem das shared socioeconomic pathways (SSPs) - trajetórias socioeconômicas compartilhadas - para construir projeções populacionais no nível subnacional, enfatizando os ganhos potenciais desta agenda no campo de população e ambiente.

Abstract During the past decades, there were scientific advances to better comprehend climate change and population dynamics. One of the main ones was the inclusion of a set of scenarios in current generation of climate modelling, with population as its human core. These are the shared socioeconomic pathways that result in population projections constructed by multi-dimensional demography, with population disaggregated by, sex, age and educational attainment. Such projections incorporate relevant population heterogeneities to adaptation and are potentially more sensitive to capture changes in demographic dynamics. This paper addresses this discussion for Brazil, considering both theoretical and methodological aspects. We highlight some of the implications of SSPs approach to construct population projections at the subnational level, emphasizing the benefits this agenda could bring to the population and environment fields.

Resumen Los avances en la ciencia para una mejor comprensión de las relaciones entre el cambio climático y la dinámica de la población se han producido en varios campos durante las últimas tres décadas. Una de las principales innovaciones se observa en la generación actual de modelos climáticos, con la inclusión de un conjunto de escenarios en los que los temas de población son centrales. Estos escenarios, denominados trayectorias socioeconómicas compartidas, esbozan alternativas para futuros desarrollos sociales que, a su vez, consideran proyecciones poblacionales multidimensionales, construidas a partir de las variables sexo, edad y educación. Estas proyecciones incorporan heterogeneidades de población relevantes para la adaptación y son potencialmente más sensibles a los cambios en la dinámica demográfica. Este artículo aborda esta discusión para Brasil, considerando sus aspectos teóricos y metodológicos. Se destacan algunas de las implicaciones del enfoque para construir proyecciones de población en el ámbito subnacional, con énfasis los logros que esta agenda puede traer al campo de población y medio ambiente.

Ilegítimos na transição entre o Império e a República: o caso do estado de São Paulo (1886-1900) / Illegitimacy in the transition between the Empire and the Republic: the case of the state of São Paulo (1886-1900) / Ilegítimos en la transición entre el imperio y la república: el caso del estado de São Paulo (1886-1900)

Resumo No Brasil, o estudo da condição de legitimidade (filiação) é tópico que vem sendo tratado pela literatura especializada, tanto no âmbito da História quanto no da Demografia Histórica, sobretudo a partir da década de 1980. O objetivo deste artigo é contribuir para o avanço da temática, mapeando a incidência e a distribuição espacial da ilegitimidade no estado de São Paulo, no final do século XIX, a partir de uma perspectiva diferente daquela dos estudos já elaborados, especialmente em relação ao recorte temporal e às fontes utilizadas. Assim, foram analisados os dados sobre a filiação na população paulista a partir dos Recenseamentos Gerais da População Brasileira, realizados em 1890 e 1900, acrescidos de outras fontes de cunho estatístico, produzidas para o estado de São Paulo. Os resultados apontam um quadro diferenciado em relação às várias zonas que compõem o estado e, embora as fontes sejam distintas, corroboraram o papel fundamental da imigração internacional, pois, nas áreas onde ela foi mais intensa, verificou-se a queda nos percentuais da ilegitimidade.

Abstract In Brazil, the study of the condition of legitimacy (affiliation) is a topic that has been studied by the specialized literature, both in the field of History and in that of Historical Demography, especially from the 1980s onwards. The objective of this article is to contribute to the advancement of the debate on illegitimacy, mapping the incidence and the spatial distribution of the phenomenon in the state of São Paulo, at the end of the 19th century, from a different perspective of previous studies, especially in relation to the considered period and the used sources. Thus, data on affiliation in the São Paulo population were analysed from the General Censuses of the Brazilian Population, carried out in 1890 and 1900, in addition to other statistical sources produced for the state of São Paulo. The results point to a different picture in relation to the various zones that make up the state of São Paulo and, although the sources are different, the results corroborate the fundamental role of international immigration, because in the areas where it was more intense, there was a decrease in the percentages of illegitimacy.

Resumen En Brasil, el estudio de la condición de legitimidad (filiación) es un tema que viene siendo abordado por la literatura especializada tanto en el campo de la Historia como en el de la Demografía Histórica, especialmente a partir de la década del ochenta del siglo XX. Es nuestra intención contribuir al avance del tema, mapeando la incidencia y la distribución espacial de la ilegitimidad en el estado de São Paulo, a finales del siglo XIX, desde una perspectiva diferente a la de estudios anteriores, en especial en relación con el marco temporal y las fuentes utilizadas. Así, los datos de afiliación en la población paulista fueron analizados a partir de los censos generales de población brasileña de 1890 y de 1900, además de otras fuentes estadísticas producidas para el estado de São Paulo. Los resultados apuntan a un cuadro diferente en relación con las diversas zonas que componen el estado de São Paulo y, aunque las fuentes son diferentes, los resultados corroboran el papel fundamental de la inmigración internacional, pues en las áreas donde fue más intensa disminuyeron los porcentajes de ilegitimidad.

Quantification of Polycyclic Aromatic Hydrocarbons in Commonly Consumed Salami in Brazil

Polycyclic aromatic hydrocarbons (PAHs) are organic compounds that have been found in different food categories, and meat products can have high concentrations of PAHs, since the technological processes to which they are subjected, such as smoking, can produce several compounds. Considering the risk that these compounds can bring to the population's health, it is essential to develop an accurate and reliable method to evaluate the contamination of PAHs in products of animal origin. The objective of this study was to optimize and validate a method for the quantification of 4 PAHs (benz[a]anthracene, chrysene, benzo[b]fluoranthene, and benzo[a]pyrene) in salami. The methodology included saponification, liquid­liquid extraction, solid-phase purification, and quantification by ultra-high-performance liquid chromatography. The effects of saponification parameters were investigated by experimental design, whereas the model obtained by regression analysis was considered satisfactory with the dissolution solvent of potassium hydroxide providing the highest global sum of areas. In validation, the parameters studied were adequate and within European and INMETRO Guidelines limits. The evaluation of 22 samples indicated that 27% were contaminated with at least one of the 4 PAHs, and benz[a]anthracene being the prevalent one with content varying between < 1.00 and 17.58 µg/kg. Two samples showed PAHs contamination above the maximum tolerable limit in the European Commission Regulation.

Pandemia da Covid-19 Efeitos no ambiente alimentar de varejo em três municípios da região metropolitana de Belo Horizonte / Covid-19 pandemic: Effects on the retail food environment in three municipalities in the metropolitan region of Belo Horizonte

Objetivo: Identificar mudanças no ambiente alimentar de varejo decorrentes da pandemia de covid-19, no ano de 2020, bem como analisar o fechamento dos estabelecimentos de venda de alimentos diante das medidas restritivas implementadas na região metropolitana de Belo Horizonte- MG. Metodologia: Estudo ecológico realizado em três cidades da região metropolitana de Belo Horizonte. Foram utilizados dados secundários da Secretaria Estadual da Fazenda, do Instituto Brasileiro de Geografia e Estatística, da Secretaria Estadual de Saúde do Estado de Minas Gerais e das e Secretarias Municipais de Saúde. Avaliaram-se as seguintes variáveis: abertura e fechamento de estabelecimentos que comercializavam alimentos segundo o tipo e categorias de estabelecimentos, sendo comparadas as medidas restritivas implementadas em cada cidade com o fechamento desses estabelecimentos. Os estabelecimentos foram classificados de acordo com o código da Classificação Nacional das Atividades Econômicas (CNAE), a partir da CNAE, os estabelecimentos de alimentos foram classificados conforme a atividade fim realizada e predominância dos alimentos comercializados, sendo agrupados seguindo os critérios apresentados no Relatório Técnico de Mapeamento de Desertos Alimentares para o Brasil elaborado pela Câmara Interministerial de Segurança Alimentar e Nutricional (CAISAN), sendo categorizados em três categorias, (1) estabelecimentos de aquisição de in natura, (2) estabelecimentos mistos, (3) estabelecimentos de aquisição de ultraprocessados. Por fim, estes estabelecimentos foram agregados segundo o perfil de aquisição e consumo de alimentos sendo agrupados em duas categorias (1) estabelecimentos para consumo imediato, (2) estabelecimentos para consumo no domicílio. Ademais, por se tratar de um estudo que avaliou o ambiente alimentar durante a pandemia de Covid-19, foram incluídas no estudo variáveis que descreviam o comportamento da pandemia nas cidades, tais como, a incidência da doença, taxa de mortalidade e medidas legislativas que foram utilizadas durante o primeiro ano da pandemia. Por fim, os estabelecimentos que fecharam em 2020 foram descritos de acordo com a vulnerabilidade do setor censitário onde estavam localizados os estabelecimentos. A vulnerabilidade foi determinada pela renda per capita do setor (renda total/ população total), foram utilizados dados do Censo Demográfico de 2010. Foi realizada análise descritiva (frequência relativa) com o auxílio do software Stata 14.0 e mapas com o uso do software QGIS 2.10.1. Resultados: Dentre os estabelecimentos que fecharam durante o primeiro ano de pandemia, a maioria comercializava alimentos para consumo imediato (Belo Horizonte 76,53%; Betim 69,95% e Contagem 70,87%). Além disso, foi possível perceber um aumento na abertura de estabelecimentos do tipo delivery nas três cidades do estudo. Apesar disso, as características gerais do ambiente alimentar de varejo se mantiveram inalteradas nas três cidades, com alta disponibilidade dos estabelecimentos que comercializavam predominantemente alimentos ultraprocessados. Conclusão: A pandemia de Covid-19 parece ter impactado mais os estabelecimentos que comercializam alimentos para consumo imediato. Contudo, ainda não é possível afirmar a dimensão do impacto gerado pela pandemia, para isso é necessário um acompanhamento a longo prazo para identificar se ocorre remodelação do ambiente alimentar

Objective: To identify changes in the retail food environment resulting from the covid-19 pandemic, in the year 2020, as well as to analyze the closure of food outlets in the face of the restrictive measures implemented in the metropolitan region of Belo Horizonte-MG. Methodology: Ecological study carried out in three cities in the metropolitan region of Belo Horizonte. Secondary data from the State Department of Finance, the Brazilian Institute of Geography and Statistics, the State Department of Health of the State of Minas Gerais and the Municipal Health Departments were used. The following variables were evaluated: opening and closing of establishments that sold food according to the type and categories of establishments, comparing the restrictive measures implemented in each city with the closure of these establishments. The establishments were classified according to the code of the National Classification of Economic Activities (CNAE), based on the CNAE, the food establishments were classified according to the core activity carried out and the predominance of food sold, being grouped according to the criteria presented in the Technical Report Mapping of Food Deserts for Brazil prepared by the Interministerial Chamber of Food and Nutritional Security (CAISAN), being categorized into three categories, (1) establishments for the acquisition of in natura, (2) mixed establishments, (3) establishments for the acquisition of ultra-processed. Finally, these establishments were aggregated according to the profile of acquisition and consumption of food, being grouped into two categories (1) establishments for immediate consumption, (2) establishments for consumption at home. Furthermore, as this is a study that evaluated the food environment during the Covid-19 pandemic, variables that described the behavior of the pandemic in cities were included in the study, such as the incidence of the disease, mortality rate and legislative measures that were used during the first year of the pandemic. Finally, establishments that closed in 2020 were described according to the vulnerability of the census sector where the establishments were located. Vulnerability was determined by the sector's per capita income (total income/total population), data from the 2010 Population Census were used. Descriptive analysis (relative frequency) was performed using Stata 14.0 software and maps using QGIS software 2.10.1. Results: Among the establishments that closed during the first year of the pandemic, most sold food for immediate consumption (Belo Horizonte 76.53%; Betim 69.95% and Contagem 70.87%). In addition, it was possible to notice an increase in the opening of delivery establishments in the three cities of the study. Despite this, the general characteristics of the retail food environment remained unchanged in the three cities, with high availability of establishments that predominantly sold ultra-processed foods. Conclusion: The Covid-19 pandemic seems to have had a greater impact on establishments that sell food for immediate consumption. However, it is still not possible to state the dimension of the impact generated by the pandemic, for which long-term monitoring is necessary to identify whether there is a remodeling of the food environment.

Domestic violence against women in the brazilian media: study of social representations / Violencia doméstica contra las mujeres en los medios de comunicación brasileños: estudio de representaciones sociales / Violência doméstica contra as mulheres na mídia brasileira: estudo de representações sociais

This study examined the content published by the newspaper Folha de São Paulo regarding domestic violence before and after Law 11340/06, commonly known as Maria da Penha Law, came into force. A retrospective and comparative documentary research analyzed 3408 news reports published between 1994 and 2018. Divided into two corpora, '12 years before' and '12 years after' the Law, the material was analyzed using the IRaMuTeQ software and Descending Hierarchical Classification. The first corpus included news reports on cases involving celebrities and little about ordinary people. It also covered the feminist struggle to reduce domestic violence, focusing on specialized police stations and shelters. The second corpus included reports on the achievements generated by the Law and its challenges, pointing out the need to regard the law as more than a punitive instrument, addressing its preventive and care spheres. Problematizing how the media discloses such law is paramount, since the content divulged affects the construction of social representations.(AU)

Este artículo tuvo por objetivo identificar el contenido de la violencia doméstica transmitido en el periódico Folha de S. Paulo antes y después de la Ley 11.340/2006 (Ley Maria da Penha). La investigación fue de carácter documental retrospectivo y comparativa, realizada a partir de 3.408 noticias difundidas entre 1994 y 2018. El material se dividió en dos corpus: 12 años antes y 12 años después de la Ley, y se analizó con el software IRaMuTeQ. En el primer corpus, los medios informaron casos de celebridades y poco sobre la gente común. También abordaron la lucha feminista para reducir la violencia doméstica. Como no existe una legislación específica, la atención se centró en estaciones de policía especializadas y refugios. En el segundo corpus, se observaron los logros generados por la Ley y sus desafíos. Se identificó la necesidad de mirar la Ley desde un punto de vista no solo punitivo, sino también abordando las esferas preventivas y de asistencia. Se enfatiza la importancia de problematizar la difusión de la Ley en los medios, ya que los contenidos generalizados afectan la construcción de las representaciones sociales.(AU)

Este artigo pretende identificar o conteúdo sobre violência doméstica difundido no jornal Folha de S. Paulo antes e depois da Lei 11340/06 (Maria da Penha). A pesquisa foi documental, retrospectiva e comparativa; com 3408 reportagens entre 1994 e 2018. O material foi dividido em dois corpora: 12 anos antes e 12 anos depois da lei, e analisado com software IRaMuTeQ. No primeiro corpus, a mídia divulgava casos de celebridades e pouco acerca de pessoas do cotidiano. Também trouxe a luta feminista para diminuir a violência doméstica. Em virtude da então inexistência de uma legislação específica, os destaques eram as delegacias especializadas e as casas abrigo. No segundo corpus, observou-se as conquistas geradas pela lei e seus desafios. Identificou-se a necessidade de olhar para a lei por um viés não apenas punitivista, abordando as esferas preventivas e assistenciais. Destaca-se a importância de problematizar a difusão da lei na mídia, visto que os conteúdos perpassados afetam a construção de representações sociais.(AU)

Meeting the ancestors.

DNA from a medieval German cemetery opens a window on the history of today's largest Jewish population.

Estimación de la frecuencia del parto vaginal instrumentado en Colombia en los años 2015 - 2019. Estudio transversal de registros poblacionales / Estimated frequency of instrumented vaginal delivery in Colombia between 2015 and 2019. Population registry-based cross-sectional study

Objetivos: evaluar la frecuencia del parto instrumentado en Colombia y por regiones entre el 2015 y 2019. Materiales y métodos: estudio de corte transversal a partir de registros poblacionales. Se incluyeron los registros de mujeres con edad gestacional mayor a 28 semanas y parto vaginal. Muestreo consecutivo. La información se obtuvo a partir del certificado de nacido vivo del Departamento Administrativo Nacional de Estadística (DANE). Se realizó la descripción de las variables sociodemográficas y clínicas. La frecuencia del parto instrumentado fue calculada y descrita por año y departamento. Resultados: se incluyeron 3.224.218 registros de recién nacidos vivos. De estos, 1.719.405 (53,33 %) correspondieron a partos vaginales, y 1.468.726 (45,55 %) a partos por vía cesárea. La frecuencia nacional del parto instrumentado entre el 2015 y 2019 fue de 36.087 nacimientos (1,11 %); Antioquia y Bogotá, D.C. fueron los lugares con mayor ocurrencia, 16.201 (4,5 %) y 13.686 (2,52 %), respectivamente. Conclusiones: el parto vaginal instrumentado es la vía de parto con menor ocurrencia en Colombia con tendencia a la disminución. La formación en este recurso para el uso durante el trabajo de parto no debe perderse en la formación del profesional de salud, especialmente en los programas de Ginecología y Obstetricia. Se debe evaluar si el aumento en el adecuado uso de esta técnica puede disminuir la tasa de cesáreas observadas actualmente, así como describir los escenarios clínicos donde su uso es seguro para la madre y el feto. Se requieren estudios prospectivos, pues pueden permitir establecer las causas del descenso en el uso de esta herramienta obstétrica, los resultados maternos y perinatales en términos de su riesgo/beneficio.

Objectives: To assess the frequency of instrumented delivery in Colombia and by regions between 2015 and 2019. Materials and methods: Cross-sectional study based on population registries. Records of women with a gestational age of more than 28 weeks and vaginal delivery were included. Consecutive sampling was used. The information was taken from live birth certificates of the National Administrative Department of Statistics (DANE). Sociodemographic and clinical variables were described. The frequency of instrumented deliveries was calculated and described by year and by department. Results: Overall, 3,224,218 live birth records were included. Of these 1,719,405 (53.33 %) were vaginal deliveries and 1,468,726 (45.55 %) were cesarean births. At a national level, the frequency of instrumented deliveries between 2015 and 2019 was 36,087 births (1.11 %); Antioquia and Bogotá, D.C. were the places with the highest occurrence, with 16,201 (4.5 %) and 13,686 (2.52 %), respectively. Conclusions: The occurrence of instrumented vaginal delivery in Colombia is the lowest and tends to diminish. Training of healthcare professionals in this approach during labor must not be abandoned, particularly in Obstetrics and Gynecology training programs. Further studies should be conducted to determine whether the increased adequate use of this technique could contribute to a lower rate of cesarean sections, and also to describe the clinical setting in which its use is safe for both the mother and the fetus. Prospective studies are required to identify the causes leading to the lower use of this obstetric tool as well as the risks and benefits in terms of maternal and perinatal outcomes.

Caminho contra a dengue: relato de experiência de um projeto de extensão universitário / Path against dengue: experience report of a university extension project / El camino contra el dengue: informe de una experiencia de un proyecto de extensión universitaria

dengue é uma doença febril aguda com etiologia viral típica e de evolução benigna que é grave quando se apresenta na forma hemorrágica. Sua transmissão ocorre pela picada do Aedes aegypti, em um ciclo humano-Aedes aegypti-humano. Sendo assim, o cuidado e a prevenção contra a dengue é uma prática que deve ser sempre incentivada, especialmente em áreas de risco, além de buscar incluir a população como partícipes nas ações de prevenção contra essa arbovirose. O artigo trata-se de um relato de experiência cujo objetivo é descrever a experiência desenvolvida e vivenciada pelos acadêmicos do curso de graduação em Medicina da UniFipMoc-Afya durante o projeto de extensão "Caminho Contra a Dengue" que ocorreu em maio de 2022 no Parque Municipal Cândido Canelas, localizado no bairro Canelas, Montes Claros ­ MG. As ações realizadas tinham caráter socioeducativo, tendo como objetivo reconhecer e demarcar os determinantes da dengue dos bairros Canelas e Antônio Canelas, para se realizar uma sensibilização da comunidade local sobre as medidas preventivas contra a proliferação da doença e, dessa forma, contribuir para a integralização da saúde dos moradores. As estratégias empregadas trouxeram a reflexão, a problematização da pauta e a valorização de uma mudança de comportamento visando à diminuição da transmissão da dengue no bairro Antônio Canelas e no Canelas. Logo, esse conjunto de experiências proporcionou a possibilidade de promover um avanço no cuidado e na prevenção da dengue, colocando a própria comunidade como precursora e responsável pelos atos que irão fornecer uma promoção da saúde e melhorias em suas vidas.

Dengue is an acute febrile illness with a typical viral etiology and a benign course that is severe when it presents in the hemorrhagic form. Its transmission occurs through the bite of Aedes aegypti, in a human-Aedes aegypti-human cycle. Therefore, care and prevention against dengue is a practice that should always be encouraged, especially in risk areas, in addition to seeking to include the population as participants in prevention actions against this arbovirus. The article is an experience report whose objective is to describe the experience developed and lived by the academics of the undergraduate course in Medicine at UniFipMoc-Afya during the extension project "Caminho Contra a Dengue" that took place in May 2022 at Parque Municipal Cândido Canelas, located in the Canelas neighborhood, Montes Claros - MG. The actions carried out had a socio-educational character, with the objective of recognizing and demarcating the determinants of dengue in the Canelas and Antônio Canelas neighborhoods, in order to raise the awareness of the local community about preventive measures against the proliferation of the disease and, in this way, contribute to the integralization of the population. residents' health. The strategies used and employed brought reflection, problematization of the agenda and the appreciation of a change in behavior aimed at reducing dengue transmission in the Antônio Canelas and Canelas neighborhoods. Therefore, this set of experiences provided the possibility of promoting progress in the care and prevention of dengue, placing the community itself as a precursor and responsible for the acts that will provide health promotion and improvements in their lives.

El dengue es una enfermedad febril aguda de etiología vírica típica y evolución benigna que es grave cuando se presenta en forma hemorrágica. Su transmisión se produce por la picadura de Aedes aegypti, en un ciclo humano-Aedes aegypti-humano. Así, el cuidado y la prevención contra el dengue es una práctica que siempre debe ser incentivada, especialmente en las zonas de riesgo, y buscar incluir a la población como partícipe de las acciones preventivas contra esta arbovirosis. El artículo es un relato de experiencia cuyo objetivo es describir la experiencia desarrollada y vivida por estudiantes de pregrado de medicina de la UniFipMoc-Afya durante el proyecto de extensión "Camino Contra el Dengue", que tuvo lugar en mayo de 2022 en el Parque Municipal Cândido Canelas, ubicado en Canelas, Montes Claros - MG. Las acciones realizadas tuvieron un carácter socioeducativo, con el objetivo de reconocer y demarcar los determinantes del dengue en los barrios Canelas y Antônio Canelas, a fin de sensibilizar a la comunidad local sobre las medidas preventivas contra la proliferación de la enfermedad y contribuir así a la integralización de la salud de los residentes. Las estrategias empleadas propiciaron la reflexión, la problematización del tema y la valorización de un cambio de comportamiento dirigido a reducir la transmisión del dengue en los barrios Antônio Canelas y Canelas. Así, este conjunto de experiencias proporcionó la posibilidad de promover un avance en la atención y prevención del dengue, colocando a la propia comunidad como precursora y responsable de actos que proporcionarán una promoción de la salud y mejoras en sus vidas.

Diagnóstico Nacional de Salud Visual en El Salvador / National Diagnosis of Visual Health in El Salvador

La salud visual se define como la ausencia de aquellas alteraciones visuales, que impiden al ser humano conseguir un estado físico, cultural, estructural y funcional de bienestar social. También es considerada como la ausencia de enfermedad ocular, acompañada de una buena agudeza visual. El Ministerio de Salud, como rector del Sistema Nacional Integrado de Salud (SNIS), ha implementado un estudio diagnóstico de la atención de la salud visual en el país, para establecer el recurso humano, capacidad instalada y portafolio de servicios con los que cuenta y que esto permita establecer políticas, lineamientos y planes que a través de diversas estrategias puedan fortalecer y generar nuevas ofertas de servicios para satisfacer la demanda de la población salvadoreña. En ese sentido, se presenta a continuación la sistematización de la recopilación de información de la red de establecimientos del SNIS, a fin de contar con la información actualizada de la situación de la salud visual según la realidad local, para que sirva de base a fin de valorar las diferentes alternativas o propuestas que permitan atender las brechas o necesidades detectadas en el tema en mención

Visual health is defined as the absence of those visual alterations that prevent the human being from achieving a physical, cultural, structural and functional state of social well-being. It is also considered as the absence of eye disease, accompanied by good visual acuity. The Ministry of Health, as rector of the National Integrated Health System (SNIS), has implemented a diagnostic study of visual health care in the country, to establish the human resources, installed capacity and portfolio of services available and that this allows the establishment of policies, guidelines and plans that through various strategies can strengthen and generate new service offers to satisfy the demand of the Salvadoran population. In this sense, the systematization of the collection of information from the network of SNIS establishments is presented below, in order to have updated information on the visual health situation according to local reality, to serve as a basis for to assess the different alternatives or proposals that allow addressing the gaps or needs detected in the subject in question

Substitution mutational signatures in whole-genome-sequenced cancers in the UK population.

Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage and repair processes that have arisen in each patient's cancer. We performed mutational signature analyses on 12,222 WGS tumor-normal matched pairs, from patients recruited via the UK National Health Service. We contrasted our results to two independent cancer WGS datasets, the International Cancer Genome Consortium (ICGC) and Hartwig Foundation, involving 18,640 WGS cancers in total. Our analyses add 40 single and 18 double substitution signatures to the current mutational signature tally. Critically, we show for each organ, that cancers have a limited number of 'common' signatures and a long tail of 'rare' signatures. We provide a practical solution for utilizing this concept of common versus rare signatures in future analyses.